TIFA full form in medical is Transcription Intermediary Factor 1 Alpha. It is a specific kind of protein that has a significant role in the operation of immune response and inflammation in the human body. It consists of the signaling routes of TLRs (Toll-Like Receptors) and the NOD (Nucleotide-binding Oligomerization). They are the major receptors that sense and respond to many danger signals and microbial pathogens in the body. Inflammatory mediators, chemokines, and cytokines are produced due to TIFA.
TIFA comprises an FHA field, which directly binds phosphoserine and phosphothreonine, and a consensus TBM. Various researchers state that TIFA is included in the pathogenesis of numerous autoimmune and inflammatory diseases, including inflammatory bowel disease, rheumatoid arthritis, and sepsis. TIFA’s dysregulation also blends in the progression and production of specific kinds of cancer. Let’s know more about TIFA in the next section.
In a recent study, it is found that TIFA plays a vital role in the regulation of host-microbe interactions and gut microbiota. It is stated that TIFA is important for producing antimicrobial peptides in the gut, maintaining the balance between pathogenic bacteria and commensal.