GIP Full Form in Medical term is gastric inhibitory polypeptide, sometimes called a glucose-dependent insulinotropic polypeptide. They are increased after consuming high-fat diets or in case of obesity. In simple words, GIP is an incretin concealed in the proximal small intestine upon the availability of nutrients in the intestine. It is also found in lipid metabolism and is believed to stimulate fat deposition.
The GIP after bariatric surgery varies depending on the type of surgery performed. Generally, the response of GIP to food is decreased after debilitating surgeries such as BPDDS and RYGB.
Gastric inhibitory polypeptide plays a crucial role in developing obesity and lipid metabolism. Hyperplasia of K-cells and increased GIP levels are observed in adiposity in obesity. This anabolic hormone restrains lipolysis and stimulates lipogenesis. It is plagiaristic from a 153 amino acid proprotein prearranged by the GIP gene and distributed as a biologically active 420-amino acid peptide. In recent studies, various experts found that the role of GIP is to induce secretion, which is mainly enthused by the hyperosmolarity of glucose in the duodenum.