The Full form of BCR in medical term is breakpoint cluster region protein. The BCR gene for humans encodes the breakpoint cluster region protein (BCR), also referred to as renal carcinoma antigen NY-REN-26. The BCR-ABL fusion protein, connected to the Philadelphia chromosome, contains two genes, BCR being one of them.
Breakpoint Cluster Region (BCR) is a gene that collaborates with ABL1 to create a fusion protein as an outcome of the reciprocal translocation of chromosomes 22 and 9. BCR is a gene that is involved in this process. The Philadelphia chromosome, a defining characteristic of chronic myelogenous leukemia, is produced by translocation (CML).
Making a protein with an unclear function is possible thanks to the BCR gene’s instructions. The BCR protein aids in controlling the migration and operation of cells. The BCR protein may function as a GTPase-activating protein, according to studies (GAP). GTPases are proteins turned off (inactivated) by GAPs and are crucial for cell chemical signaling. GTPases are known molecular switches since they can be activated and deactivated. They become active whenever they are connected to or bonded to the molecule GTP; whenever they are connected to or bound to the molecule GDP, they become inactive.
The BCR protein can function as a kinase. This enzyme modifies the activity of many other proteins by introducing a distinct positional cluster of oxygen plus phosphorus atoms (a phosphate group). Even though its precise function is unknown, BCR’s kinase activity is essential in controlling cell signaling.